It’s a vicious cycle: the bliss one feels from Friday around 6 p.m. until Sunday at around the same time, when it hits you like a two-by-four — the Sunday blues.

Finally a cure: Sunday supper at Saison, the new, open-just-once-a-week Mission restaurant from uber-talented chef Joshua Skenes and sommelier wunderkind Mark Bright, debuting this weekend.

Housed in a historic stable in the Mission, the spot feels like home: Enter through the kitchen and take a seat in the sleek gallery-slash-dining room or on the patio under citrus trees and bougainvillea.

Weekend warriors will find sustainable, organic sustenance in Skenes’s four-course New American menus, which might include things like four-story poularde with podi spices, erbette chard, almond milk, and roasting jus. Ingredients are sourced from small local farms and ranches. Wine selections follow suit.

How’s that for warm and fuzzy?

Saison, 2124 Folsom Street, at 17th Street (415-828-7990 or saisonsf.com).

Photo: Courtesy of Saison